Mfge8^tm1Mcu
Targeted Allele Detail

Summary

• Symbol: Mfge8^tm1Mcu
• Name: milk fat globule EGF and factor V/VIII domain containing; targeted mutation 1, Mark C Udey
• MGI ID: MGI:3717588
• Synonyms: Mfge8^-
• Gene: Mfge8 Location: Chr7:78783516-78798808 bp, - strand Genetic Position: Chr7, 44.9 cM
• Alliance: Mfge8^tm1Mcu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123138
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exons 2 to 6. (J:123138)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mfge8 Mutation: 23 strains or lines available

References

• Original: J:123138 Neutzner M, et al., MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis. Cancer Res. 2007 Jul 15;67(14):6777-85
• All: 5 reference(s)