Tg(Eno2-PTGS2)32Pasi
Transgene Detail

Summary

• Symbol: Tg(Eno2-PTGS2)32Pasi
• Name: transgene insertion 32, Guilio Maria Pasinetti
• MGI ID: MGI:3717604
• Synonyms: hCOX-2, hCOX-2 transgenic, NHC32
• Transgene: Tg(Eno2-PTGS2)32Pasi Location: unknown
• Alliance: Tg(Eno2-PTGS2)32Pasi page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-PTGS2)32Pasi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTGS2 (5743)

  Ptgs2

  (MGI:97798)

• Mutation details: The 1950 bp cDNA for the entire coding region of human PTGS2 was inserted into the second exon of the rat neuron-specific enolase gene (Eno2). The construct also contains the polyadenylation signal from the SV40 late region. This construct was microinjected into one-cell B6C3F1 mouse oocytes. Transgene mRNA is expressed only in the brain as shown by Northern blot, and Western blot showed human PTGS2 protein expression in brain tissue homogenates. (J:100973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100973 Kelley KA, et al., Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am J Pathol. 1999 Sep;155(3):995-1004
• All: 3 reference(s)