Ptpn6^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptpn6^m1Btlr
• Name: protein tyrosine phosphatase, non-receptor type 6; mutation 1, Bruce Beutler
• MGI ID: MGI:3717648
• Synonyms: Ptpn^spin, SHP1^Y208N, Spin
• Gene: Ptpn6 Location: Chr6:124697670-124715672 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Ptpn6^m1Btlr page

Chronic inflammation in Ptpn6^m1Btlr/Ptpn6^m1Btlr mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• This mutation results in a Y208N substitution in the C-SH2 domain of the encoded protein. (J:94077, J:142845)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn6 Mutation: 49 strains or lines available

References

• Original: J:142845 Croker BA, et al., Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15028-33
• All: 10 reference(s)