Tg(PDGFB-APPInd)H6Lms
Transgene Detail

Summary

• Symbol: Tg(PDGFB-APPInd)H6Lms
• Name: transgene insertion H6, Lennart Mucke
• MGI ID: MGI:3717672
• Synonyms: APPInd, PDGF-hAPP line 6, PDGF-hAPP line H6, Tg(PDGFB-APP*Ind)H6Lms, Tg(PDGFB-APP*V717F)H6Lms
• Transgene: Tg(PDGFB-APPInd)H6Lms Location: unknown
• Alliance: Tg(PDGFB-APPInd)H6Lms page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-APPInd)H6Lms expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: The transgene contains a human APP minigene encoding the Indiana mutation (V717F) which is associated with familial Alzheimer disease. The construct contained APP introns 6-8, allowing alternative splicing of exons 7 and 8. The human PDGF beta-chain promoter drives expression, and the construct also contains the SV40 polyadenylation signal. Amyloid-beta ELISA on whole brain homogenates indicates higher cerebral beta-amyloid production than in Tg(APPV717F)109Ili mice expressing the same construct. (J:100980, J:102272)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:102272 Wyss-Coray T, et al., Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature. 1997 Oct 9;389(6651):603-6
• All: 4 reference(s)