Tg(KRT14-rtTA)208Jek
Transgene Detail

Summary

• Symbol: Tg(KRT14-rtTA)208Jek
• Name: transgene insertion 208, Jeffrey E Kudlow
• MGI ID: MGI:3717751
• Synonyms: K14-rtTA, K14-rtTA(X), K14-X, rtTA(X), X-linked K14-rtTA
• Transgene: Tg(KRT14-rtTA)208Jek Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(KRT14-rtTA)208Jek page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The K14-rtTA transgene contains the 2.3 kb fragment of the human keratin 14 promoter that drives expression of the reverse tetracycline transactivator gene (rtTA), followed by an SV40 polyadenylation sequence. The 4.9 kb transgene was injected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder line 208 found to harbor the transgene on the X chromosome (also called founder line K14-X). Random X inactivation may result in mosaic rtTA expression patterns in female mice. The transgene when combined with mice carrying a gene under the control of a tetracycline-responsive promoter allows doxycycline-inducible gene expression in skin cells. (J:55970, J:96886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96886 Foster KW, et al., Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 2005 Feb 24;24(9):1491-500
• All: 23 reference(s)