Tg(KRT14-rtTA)208Jek
Transgene Detail
|
Symbol: |
Tg(KRT14-rtTA)208Jek |
Name: |
transgene insertion 208, Jeffrey E Kudlow |
MGI ID: |
MGI:3717751 |
Synonyms: |
K14-rtTA, K14-rtTA(X), K14-X, rtTA(X), X-linked K14-rtTA |
Transgene: |
Tg(KRT14-rtTA)208Jek Location: unknown Genetic Position: ChrX, Syntenic
|
Alliance: |
Tg(KRT14-rtTA)208Jek page
|
|
Strain of Origin: |
(C57BL/6 x SJL)
|
|
Transgene Type: |
|
Transgenic (Transactivator) |
Mutation: |
|
Insertion
|
|
|
Mutation details: The K14-rtTA transgene contains the 2.3 kb fragment of the human keratin 14 promoter that drives expression of the reverse tetracycline transactivator gene (rtTA), followed by an SV40 polyadenylation sequence. The 4.9 kb transgene was injected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder line 208 found to harbor the transgene on the X chromosome (also called founder line K14-X). Random X inactivation may result in mosaic rtTA expression patterns in female mice. The transgene when combined with mice carrying a gene under the control of a tetracycline-responsive promoter allows doxycycline-inducible gene expression in skin cells.
(J:55970, J:96886)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
Original: |
J:96886 Foster KW, et al., Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 2005 Feb 24;24(9):1491-500 |
All: |
22 reference(s) |
|