Tg(tetO-KLF4)32831Rup
Transgene Detail

Summary

• Symbol: Tg(tetO-KLF4)32831Rup
• Name: transgene insertion 32831, J Michael Ruppert
• MGI ID: MGI:3717763
• Synonyms: TRE-KLF4, TRE-KLF4³²⁸³¹
• Transgene: Tg(tetO-KLF4)32831Rup Location: unknown
• Alliance: Tg(tetO-KLF4)32831Rup page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-KLF4)32831Rup expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KLF4 (9314)

  Klf4	(MGI:1342287)

• Mutation details: The protein-coding region of the human Kruppel-like factor gene KLF4 was ligated to a vector fragment containing a tetracycline-responsive element and the minimal human cytomegalovirus promoter to produce the transgene construct. The 4.4 kb fragment was injected into (C57BL/6 x SJL)F2 ova. (J:96886)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96886 Foster KW, et al., Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 2005 Feb 24;24(9):1491-500
• All: 3 reference(s)