Spi1^tm1Rpd
Targeted Allele Detail

Summary

• Symbol: Spi1^tm1Rpd
• Name: Spi-1 proto-oncogene; targeted mutation 1, Rodney P DeKoter
• MGI ID: MGI:3717917
• Synonyms: Sfpi1^BN
• Gene: Spi1 Location: Chr2:90912750-90946104 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E3
• Alliance: Spi1^tm1Rpd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123079
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace both translation start sites with beta-lactamase and a floxed PGK-neo. (J:123079)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spi1 Mutation: 28 strains or lines available

References

• Original: J:123079 Houston IB, et al., Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality. Exp Hematol. 2007 Jul;35(7):1056-68
• All: 3 reference(s)