Hdac1^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Hdac1^tm1.1Eno
• Name: histone deacetylase 1; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:3717923
• Synonyms: Hdac1^loxP
• Gene: Hdac1 Location: Chr4:129409897-129436506 bp, - strand Genetic Position: Chr4, 63.26 cM
• Alliance: Hdac1^tm1.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123173
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 5-7 of the locus. This sequence contains several key histidine and aspartic acid residues required for catalytic activity. A neo cassette flanked by FRT sites was removed from the locus by crossing with mice expressing Flp recombinase in the germline. (J:123173)

Expression

In Mice Carrying this Mutation:	9 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac1 Mutation: 38 strains or lines available

References

• Original: J:123173 Montgomery RL, et al., Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev. 2007 Jul 15;21(14):1790-802
• All: 32 reference(s)