Hdac2^tm1.2Eno
Targeted Allele Detail

Summary

• Symbol: Hdac2^tm1.2Eno
• Name: histone deacetylase 2; targeted mutation 1.2, Eric N Olson
• MGI ID: MGI:3717930
• Synonyms: Hdac2^-
• Gene: Hdac2 Location: Chr10:36850540-36877885 bp, + strand Genetic Position: Chr10, 19.44 cM, cytoband B1
• Alliance: Hdac2^tm1.2Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123173
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2-4 were removed via cre mediated recombination. RT-PCR detected a complete absence of mRNA encoding exons 2-4, but the presence of alternatively spliced transcripts downstream of the deletion. Protein expression was not detected from these transcripts. (J:123173)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac2 Mutation: 40 strains or lines available

References

• Original: J:123173 Montgomery RL, et al., Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev. 2007 Jul 15;21(14):1790-802
• All: 5 reference(s)