Rgs10^tm1Ypl
Targeted Allele Detail

Summary

• Symbol: Rgs10^tm1Ypl
• Name: regulator of G-protein signalling 10; targeted mutation 1, Yi-Ping Li
• MGI ID: MGI:3717931
• Synonyms: Rgs10^-
• Gene: Rgs10 Location: Chr7:127975345-128020482 bp, - strand Genetic Position: Chr7, 70.16 cM
• Alliance: Rgs10^tm1Ypl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123167
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neomycin resistance cassette. This exon encodes amino acids 85-133, covering most of the RGS domain. Absence of transcript was confirmed by Northern blot analysis. (J:123167)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs10 Mutation: 16 strains or lines available

References

• Original: J:123167 Yang S, et al., RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation. Genes Dev. 2007 Jul 15;21(14):1803-16
• All: 1 reference(s)