Unc119^tm1Gina
Targeted Allele Detail

Summary

• Symbol: Unc119^tm1Gina
• Name: unc-119 lipid binding chaperone; targeted mutation 1, George Inana
• MGI ID: MGI:3718005
• Gene: Unc119 Location: Chr11:78234321-78239990 bp, + strand Genetic Position: Chr11, 46.74 cM, cytoband B5
• Alliance: Unc119^tm1Gina page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123195
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The distal region of exon 1 and intron 1 were replaced with a neomycin resistance gene. A stop codon incorporated at the junction was used to prevent run-on translation. (J:123195)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc119 Mutation: 12 strains or lines available

References

• Original: J:123195 Ishiba Y, et al., Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. Exp Eye Res. 2007 Mar;84(3):473-85
• All: 4 reference(s)