Cacna1atm1(CACNA1A)Ttan
Targeted Allele Detail
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Symbol: |
Cacna1atm1(CACNA1A)Ttan |
Name: |
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1, Tsutomu Tanabe |
MGI ID: |
MGI:3718032 |
Synonyms: |
HL28ki(+) |
Gene: |
Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
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Alliance: |
Cacna1atm1(CACNA1A)Ttan page
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Germline Transmission: |
Earliest citation of germline transmission:
J:123243
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, RMCE-ready) |
Mutation: |
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Insertion
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Cacna1atm1(CACNA1A)Ttan expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CACNA1A (773) |
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Mutation details: A neomycin resistance cassette flanked by loxP and lox71 was inserted into exon 1. A knock-in vector containing plox66-HL28NP was inserted along with a cre-expressing plasmid, resulting in the replacement of the neo with the knock-in vector. The vector contained lox66, IRES, human cDNA encoding the calcium channel, voltage-dependent, P/Q type, alpha 1A subunit gene from HL28NP (GenBank AB035726), a polyA signal and an FRT-flanked CAG-hygro gene. The human gene contained 28 polyglutamine repeats.
(J:123243)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cacna1a Mutation: |
118 strains or lines available
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Original: |
J:123243 Saegusa H, et al., Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells. Mol Cell Neurosci. 2007 Feb;34(2):261-70 |
All: |
1 reference(s) |
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