About   Help   FAQ
Cacna1atm1(CACNA1A)Ttan
Targeted Allele Detail
Summary
Symbol: Cacna1atm1(CACNA1A)Ttan
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1, Tsutomu Tanabe
MGI ID: MGI:3718032
Synonyms: HL28ki(+)
Gene: Cacna1a  Location: Chr8:85065268-85366875 bp, + strand  Genetic Position: Chr8, 40.95 cM
Alliance: Cacna1atm1(CACNA1A)Ttan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123243
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, RMCE-ready)
Mutation:    Insertion
 
Cacna1atm1(CACNA1A)Ttan expresses 1 gene
 
Mutation detailsA neomycin resistance cassette flanked by loxP and lox71 was inserted into exon 1. A knock-in vector containing plox66-HL28NP was inserted along with a cre-expressing plasmid, resulting in the replacement of the neo with the knock-in vector. The vector contained lox66, IRES, human cDNA encoding the calcium channel, voltage-dependent, P/Q type, alpha 1A subunit gene from HL28NP (GenBank AB035726), a polyA signal and an FRT-flanked CAG-hygro gene. The human gene contained 28 polyglutamine repeats. (J:123243)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1a Mutation:  118 strains or lines available
References
Original:  J:123243 Saegusa H, et al., Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells. Mol Cell Neurosci. 2007 Feb;34(2):261-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory