Grin2c^tm1Bnno
Targeted Allele Detail

Summary

• Symbol: Grin2c^tm1Bnno
• Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3); targeted mutation 1, Andres Buonanno
• MGI ID: MGI:3718038
• Synonyms: Nr2c^nlacZ
• Gene: Grin2c Location: Chr11:115139995-115158069 bp, - strand Genetic Position: Chr11, 80.8 cM
• Alliance: Grin2c^tm1Bnno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123236
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The nlacZ reporter gene was inserted into the translation initiation codon of the gene such that it replaced exons encoding the translation initiation site down to the fourth transmembrane domain. A floxed neo cassette was included in the vector and subsequently removed by cre mediated recombination. (J:123236)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2c Mutation: 56 strains or lines available

References

• Original: J:123236 Karavanova I, et al., Novel regional and developmental NMDA receptor expression patterns uncovered in NR2C subunit-beta-galactosidase knock-in mice. Mol Cell Neurosci. 2007 Mar;34(3):468-80
• All: 8 reference(s)