Tg(Hmgcr-MAPT)23Brio
Transgene Detail

Summary

• Symbol: Tg(Hmgcr-MAPT)23Brio
• Name: transgene insertion 23, Jean-Pierre Brion
• MGI ID: MGI:3718047
• Synonyms: TG23
• Transgene: Tg(Hmgcr-MAPT)23Brio Location: unknown
• Alliance: Tg(Hmgcr-MAPT)23Brio page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Hmgcr-MAPT)23Brio expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The cDNA encoding the three-repeat human fetal tau (MAPT) protein (shortest human isoform) without the N-terminal insert was inserted after the mouse Hmgcr promoter region, exon 1 (not translated) and major intron 1, in the pHMG vector. The construct was microinjected into (C57BL/6J x CBA)F2 fertilized embryos. Line 23 was established. Human tau (MAPT) protein is detected in cell bodies and dendrites of neurons in many brain areas in adult animals with Western blots. (J:101993)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:101993 Brion JP, et al., Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease. Am J Pathol. 1999 Jan;154(1):255-70
• All: 4 reference(s)