Slc2a4^tm1Jdz
Targeted Allele Detail

Summary

• Symbol: Slc2a4^tm1Jdz
• Name: solute carrier family 2 (facilitated glucose transporter), member 4; targeted mutation 1, Jeffrey D Zajac
• MGI ID: MGI:3718071
• Synonyms: GLUT4-Lox+
• Gene: Slc2a4 Location: Chr11:69833365-69839014 bp, - strand Genetic Position: Chr11, 42.93 cM, cytoband C-E1
• Alliance: Slc2a4^tm1Jdz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123335
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites to flank exons 7-11 and insert a neomycin resistance cassette immediately downstream of exon 11. Protein expression is reduced in homozygous muscle and adipose tissue to 30% and 16 - 20% of wild-type, respectively. (J:123335)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a4 Mutation: 35 strains or lines available

References

• Original: J:123335 Kaczmarczyk SJ, et al., Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy. J Mol Endocrinol. 2003 Dec;31(3):449-59
• All: 4 reference(s)