Mef2c^tm2Eno
Targeted Allele Detail

Summary

• Symbol: Mef2c^tm2Eno
• Name: myocyte enhancer factor 2C; targeted mutation 2, Eric N Olson
• MGI ID: MGI:3718323
• Synonyms: MEF2C^fl, Mef2c^loxP
• Gene: Mef2c Location: Chr13:83652153-83815199 bp, + strand Genetic Position: Chr13, 43.68 cM
• Alliance: Mef2c^tm2Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119152
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted in the introns flanking the second coding exon. The neomycin resistance cassette was removed by breeding with mice expressing FLPe recombinase in the germline. (J:119152)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mef2c Mutation: 34 strains or lines available

References

• Original: J:119152 Arnold MA, et al., MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell. 2007 Mar;12(3):377-89
• All: 29 reference(s)