App^tm1Umu
Targeted Allele Detail

Summary

• Symbol: App^tm1Umu
• Name: amyloid beta precursor protein; targeted mutation 1, Ulrike C Muller
• MGI ID: MGI:3718442
• Synonyms: APPsalpha^-, APPsalpha-KI, APPs^salpha
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm1Umu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123316
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A stop codon was introduced into exon 16 behind the alpha-secretase site at position QK612, flanked by a SV40 polyA site to ensure efficient polyadenylation of the mRNA. A floxed neo was removed via transient cre expression. (J:123316)

Expression

In Mice Carrying this Mutation:

24 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 105 strains or lines available

References

• Original: J:123316 Ring S, et al., The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci. 2007 Jul 18;27(29):7817-26
• All: 8 reference(s)