App^tm2Umu
Targeted Allele Detail

Summary

• Symbol: App^tm2Umu
• Name: amyloid beta precursor protein; targeted mutation 2, Ulrike C Muller
• MGI ID: MGI:3718443
• Synonyms: APPdeltaCT15
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm2Umu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123316
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This mutation is a deletion lacking the sequences encoding the last 15 amino acids of the locus, harboring the YENPTY motif. (J:123316)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 105 strains or lines available

References

• Original: J:123316 Ring S, et al., The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci. 2007 Jul 18;27(29):7817-26
• All: 4 reference(s)