Atg4c^tm1Otin
Targeted Allele Detail

Summary

• Symbol: Atg4c^tm1Otin
• Name: autophagy related 4C, cysteine peptidase; targeted mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:3718523
• Synonyms: Atg4c^-
• Gene: Atg4c Location: Chr4:99082171-99148024 bp, + strand Genetic Position: Chr4, 45.61 cM
• Alliance: Atg4c^tm1Otin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123386
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A pgk-neo cassette replaced exons 1-4 of the locus, including sequences encoding the catalytic domain. RT-PCR confirmed absence of transcript in mutant brain, testis, liver and kidney samples. (J:123386)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atg4c Mutation: 26 strains or lines available

References

• Original: J:123386 Marino G, et al., Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem. 2007 Jun 22;282(25):18573-83
• All: 3 reference(s)