Foxp3^tm1Kuch
Targeted Allele Detail

Summary

• Symbol: Foxp3^tm1Kuch
• Name: forkhead box P3; targeted mutation 1, Vijay K Kuchroo
• MGI ID: MGI:3718527
• Synonyms: Fox3^eGFP, Foxp3-eGFP, Foxp3eGFP, Foxp3-GFP, Foxp3/GFP⁺, Foxp3-GFP.KI, Foxp3gfp.KI, Foxp3-IRES-GFP
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^tm1Kuch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123469
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A bicistronic enhanced green fluorescent protein reporter (IRES-GFP) was inserted into the locus. EGFP can be used to faithfully track the expression of the endogenous gene. No disruption to Foxp3 gene function or expression is observed. (J:123469)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 58 strains or lines available

References

• Original: J:123469 Bettelli E, et al., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11;441(7090):235-8
• All: 185 reference(s)