Tg(Col2a1-Mef2c/en)1Eno
Transgene Detail

Summary

• Symbol: Tg(Col2a1-Mef2c/en)1Eno
• Name: transgene insertion 1, Eric N Olson
• MGI ID: MGI:3718996
• Synonyms: Col2-MEF2C-Engrailed
• Transgene: Tg(Col2a1-Mef2c/en)1Eno Location: unknown
• Alliance: Tg(Col2a1-Mef2c/en)1Eno page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene expresses a fusion protein of the murine Mef2c DNA-binding domain and the Drosophila Engrailed repressor in proliferating chondrocytes under the control of the murine Col2a1 promoter. This Mef2c-engrailed fusion protein inactivates all Mef2 proteins by preventing DNA binding and creating transcriptionally inactive heterodimers with wild-type Mef2 proteins. (J:119152)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:119152 Arnold MA, et al., MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell. 2007 Mar;12(3):377-89
• All: 1 reference(s)