Adprh^tm1Jlms
Targeted Allele Detail

Summary

• Symbol: Adprh^tm1Jlms
• Name: ADP-ribosylarginine hydrolase; targeted mutation 1, Joel Moss
• MGI ID: MGI:3719093
• Synonyms: Adprh^-
• Gene: Adprh Location: Chr16:38265761-38273051 bp, - strand Genetic Position: Chr16, 26.86 cM, cytoband B4
• Alliance: Adprh^tm1Jlms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123619
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, including the critical catalytic site residues D60 and D61, was replaced with a neomycin resistance cassette. Transcript was not detected in mutant mice and immunoblotting confirmed absence of protein. (J:123619)

Tumor Data

List all tumor models in MMHCdb carrying Adprh^tm1Jlms

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adprh Mutation: 36 strains or lines available

References

• Original: J:123619 Kato J, et al., Enhanced sensitivity to cholera toxin in ADP-ribosylarginine hydrolase-deficient mice. Mol Cell Biol. 2007 Aug;27(15):5534-43
• All: 5 reference(s)