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Bcl6btm2Dent
Targeted Allele Detail
Summary
Symbol: Bcl6btm2Dent
Name: B cell CLL/lymphoma 6, member B; targeted mutation 2, Alexander Dent
MGI ID: MGI:3719094
Synonyms: Bazf-
Gene: Bcl6b  Location: Chr11:70114954-70120624 bp, - strand  Genetic Position: Chr11, 42.99 cM, cytoband B4
Alliance: Bcl6btm2Dent page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123621
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region encoding 124 C-terminal amino acids was replaced by a pgk-neo cassette. This deleted region contained all of the zinc finger amino acids, and thus the targeted gene was rendered incapable of producing a DNA binding protein by alternative splicing. RT-PCR confirmed absence of transcript from mutant lungs. (J:123621)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl6b Mutation:  16 strains or lines available
References
Original:  J:123621 Broxmeyer HE, et al., Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice. Mol Cell Biol. 2007 Aug;27(15):5275-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory