Rab8a^tm1Aha
Targeted Allele Detail

Summary

• Symbol: Rab8a^tm1Aha
• Name: RAB8A, member RAS oncogene family; targeted mutation 1, Akihiro Harada
• MGI ID: MGI:3719350
• Synonyms: Rab8a^geo
• Gene: Rab8a Location: Chr8:72915044-72935210 bp, + strand Genetic Position: Chr8, 34.84 cM
• Alliance: Rab8a^tm1Aha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123415
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector inserted a Bcl2 splice acceptor, IRES and an frt-flanked neo, with a loxP site on the 5' end of the cassette into intron 1. An additional loxP site was inserted into intron 2. The insertion of the cassette inactivated the locus. (J:123415)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab8a Mutation: 18 strains or lines available

References

• Original: J:123415 Sato T, et al., The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature. 2007 Jul 19;448(7151):366-9
• All: 1 reference(s)