Pdyn^tm1Zim
Targeted Allele Detail

Summary

• Symbol: Pdyn^tm1Zim
• Name: prodynorphin; targeted mutation 1, Andreas Zimmer
• MGI ID: MGI:3719377
• Synonyms: Pdyn^-
• Gene: Pdyn Location: Chr2:129528485-129541764 bp, - strand Genetic Position: Chr2, 63.19 cM
• Alliance: Pdyn^tm1Zim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123424
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 and part of exon 4 were deleted from the locus. This sequence includes the translation initiation codon. Absence of protein was confirmed in mutant mice. (J:123424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdyn Mutation: 20 strains or lines available

Notes

ES cell line = "MPIII" (J:123424).

References

• Original: J:123424 Zimmer A, et al., Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J Neurosci. 2001 Dec 1;21(23):9499-505
• All: 8 reference(s)