Slc26a5^tm2Jnz
Targeted Allele Detail

Summary

• Symbol: Slc26a5^tm2Jnz
• Name: solute carrier family 26, member 5; targeted mutation 2, Jian Zuo
• MGI ID: MGI:3719391
• Synonyms: C1 prestin KI
• Gene: Slc26a5 Location: Chr5:22015653-22070602 bp, - strand Genetic Position: Chr5, 9.97 cM, cytoband A3
• Alliance: Slc26a5^tm2Jnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123299
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The C1 mutation was introduced into exon 7 of the locus. This mutation contains the K233Q, K235Q, and R236Q substitutions. A floxed neo was inserted into intron 6 and subsequently removed via cre mediated recombination. (J:123299)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a5 Mutation: 58 strains or lines available

References

• Original: J:123299 Gao J, et al., Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12542-7
• All: 3 reference(s)