Erf^tm1Gmav
Targeted Allele Detail

Summary

• Symbol: Erf^tm1Gmav
• Name: Ets2 repressor factor; targeted mutation 1, George Mavrothalassitis
• MGI ID: MGI:3719472
• Synonyms: Erf^-, Erf^dl1, ErfKO
• Gene: Erf Location: Chr7:24941986-24950186 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Erf^tm1Gmav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123628
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector replaced exons 2, 3 and part of exon 4, sequences that encode the DNA binding domain, with a floxed neomycin resistance cassette. Expression of a cre transgene carried by the parental ES cells removed the floxed neo cassette upon passage through the male germline. Northern blot confirmed absence of transcript in mutant mice. (J:123628)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erf Mutation: 31 strains or lines available

References

• Original: J:123628 Papadaki C, et al., Transcriptional repressor erf determines extraembryonic ectoderm differentiation. Mol Cell Biol. 2007 Jul;27(14):5201-13
• All: 4 reference(s)