B9d2/Tgfb1^tm1Flv
Targeted Allele Detail

Summary

• Symbol: B9d2/Tgfb1^tm1Flv
• Name: transforming growth factor, beta 1; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3719581
• Synonyms: Tgfb1^f
• Gene: Tgfb1 Location: Chr7:25386427-25404502 bp, + strand Genetic Position: Chr7, 13.98 cM
• Alliance: B9d2/Tgfb1^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123547
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the promoter region and exon 1 of transforming growth factor, beta 1 as well as B9 protein domain 2. A floxed neo included in the vector was removed via transient cre expression. (J:123547)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfb1 Mutation: 35 strains or lines available

References

• Original: J:123547 Li MO, et al., T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity. 2007 May;26(5):579-91
• All: 16 reference(s)