Ptpn6^tm1Rsky
Targeted Allele Detail

Summary

• Symbol: Ptpn6^tm1Rsky
• Name: protein tyrosine phosphatase, non-receptor type 6; targeted mutation 1, Klaus Rajewsky
• MGI ID: MGI:3719625
• Synonyms: Ptpn6^f, SHP-1^Flox
• Gene: Ptpn6 Location: Chr6:124697670-124715672 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Ptpn6^tm1Rsky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123568
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A vector was designed to flank exon 1 through exon 9 with loxP sites. A floxed neo was removed via transient cre expression. (J:123568)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn6 Mutation: 49 strains or lines available

References

• Original: J:123568 Pao LI, et al., B cell-specific deletion of protein-tyrosine phosphatase shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity. 2007 Jul;27(1):35-48
• All: 43 reference(s)