Icos^tm1Dgry
Targeted Allele Detail

Summary

• Symbol: Icos^tm1Dgry
• Name: inducible T cell co-stimulator; targeted mutation 1, David Gray
• MGI ID: MGI:3719635
• Synonyms: Icos^-
• Gene: Icos Location: Chr1:61017086-61039479 bp, + strand Genetic Position: Chr1, 30.6 cM
• Alliance: Icos^tm1Dgry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123477
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ-neo was inserted into the locus to replace almost all of exon 2 and all of exons 3 and 4. (J:123477)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icos Mutation: 37 strains or lines available

References

• Original: J:123477 Mahajan S, et al., The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. Eur J Immunol. 2007 Jul;37(7):1796-808
• All: 2 reference(s)