Lhx1^tm4Bhr
Targeted Allele Detail

Summary

• Symbol: Lhx1^tm4Bhr
• Name: LIM homeobox protein 1; targeted mutation 4, Richard R Behringer
• MGI ID: MGI:3719681
• Synonyms: Lhx1^fx1
• Gene: Lhx1 Location: Chr11:84409110-84416361 bp, - strand Genetic Position: Chr11, 51.31 cM
• Alliance: Lhx1^tm4Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123471
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the first intron and a floxed neo cassette was inserted into the fourth intron. (J:123471)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx1 Mutation: 22 strains or lines available

References

• Original: J:123471 Zhao Y, et al., LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13182-6
• All: 1 reference(s)