Ldb1^tm2Lmgd
Targeted Allele Detail

Summary

• Symbol: Ldb1^tm2Lmgd
• Name: LIM domain binding 1; targeted mutation 2, Laboratory of Mammalian Genes and Development, Heiner Westphal
• MGI ID: MGI:3719683
• Synonyms: Ldb1^fl
• Gene: Ldb1 Location: Chr19:46020009-46033653 bp, - strand Genetic Position: Chr19, 38.75 cM
• Alliance: Ldb1^tm2Lmgd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123471
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the coding region and a floxed neo cassette was inserted into the ninth intron. In vivo cre mediated recombination removed the neo cassette leaving a single loxP site in the ninth intron (J:123471)

Expression

In Mice Carrying this Mutation:	93 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldb1 Mutation: 35 strains or lines available

References

• Original: J:123471 Zhao Y, et al., LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13182-6
• All: 16 reference(s)