H2-T23^tm2Cant
Targeted Allele Detail

Summary

• Symbol: H2-T23^tm2Cant
• Name: histocompatibility 2, T region locus 23; targeted mutation 2, Harvey Cantor
• MGI ID: MGI:3719723
• Synonyms: Qa-1 R72A
• Gene: H2-T23 Location: Chr17:36340869-36343593 bp, - strand Genetic Position: Chr17, 18.86 cM
• Alliance: H2-T23^tm2Cant page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123555
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector inserted a floxed neo into intron 3 and the R72A mutation into exon 3. The neo was removed via cre mediated recombination. (J:123555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-T23 Mutation: 35 strains or lines available

References

• Original: J:123555 Lu L, et al., Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007 May;26(5):593-604
• All: 7 reference(s)