Foxo3^tm1Nmt
Targeted Allele Detail

Summary

• Symbol: Foxo3^tm1Nmt
• Name: forkhead box O3; targeted mutation 1, Noboru Motoyama
• MGI ID: MGI:3719789
• Synonyms: Foxo3a^-
• Gene: Foxo3 Location: Chr10:42057841-42152691 bp, - strand Genetic Position: Chr10, 22.79 cM
• Alliance: Foxo3^tm1Nmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123409
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced with a neo cassette. (J:142870)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Foxo3^tm1Nmt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxo3 Mutation: 51 strains or lines available

References

• Original: J:123409 Huntington ND, et al., Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol. 2007 Aug;8(8):856-863
• All: 16 reference(s)