Lats2^tm1Noj
Targeted Allele Detail

Summary

• Symbol: Lats2^tm1Noj
• Name: large tumor suppressor 2; targeted mutation 1, Hiroshi Nojima
• MGI ID: MGI:3719818
• Synonyms: Lats2^-
• Gene: Lats2 Location: Chr14:57927119-57983669 bp, - strand Genetic Position: Chr14, 30.28 cM
• Alliance: Lats2^tm1Noj page

Lats2^tm1Noj/Lats2^tm1Noj embryos exhibit severe nervous system developmental defects

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123480
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The entire coding region was disrupted by replacing the first coding exon with the neo cassette. (J:123480)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lats2 Mutation: 44 strains or lines available

References

• Original: J:123480 Yabuta N, et al., Lats2 is an essential mitotic regulator required for the coordination of cell division. J Biol Chem. 2007 Jun 29;282(26):19259-71
• All: 3 reference(s)