Tg(CAG-APP)0304Shoj
Transgene Detail

Summary

• Symbol: Tg(CAG-APP)0304Shoj
• Name: transgene insertion 0304, Mikio Shoji
• MGI ID: MGI:3720041
• Synonyms: AB-NOR Beta, BA-NOR Beta, NOR Beta, Tg(ACTB-APP)0304Shoj, Tg(CAG-APP)0304Shoj
• Transgene: Tg(CAG-APP)0304Shoj Location: unknown
• Alliance: Tg(CAG-APP)0304Shoj page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1 X C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-APP)0304Shoj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: A transgene construct composed of the signal peptide and 99 residues of the carboxy-terminal fragment of human amyloid beta precursor protein (BAPP) under control of the cytomegalovirus enhancer/chicken beta-actin (ACTB) promoter was injected into fertilized (C57BL/6 x C3H)F1 x C57BL/6N hybrid mouse oocytes. Transgenic mRNA was detected in many tissues. Amyloid beta was detected biochemically in brain, kidney, and to the largest extent in the pancreas. Marked accumulation of human amyloid beta peptides 30-fold higher than in normal human plasma) was found in plasma of transgenic mice. (J:100977)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100977 Kawarabayashi T, et al., Accumulation of beta-amyloid fibrils in pancreas of transgenic mice. Neurobiol Aging. 1996 Mar-Apr;17(2):215-22
• All: 2 reference(s)