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Tg(Thy1-App*R609D*K612E)6Vln
Transgene Detail
Summary
Symbol: Tg(Thy1-App*R609D*K612E)6Vln
Name: transgene insertion 6, Fred Van Leuven
MGI ID: MGI:3720071
Synonyms: t/RK/F/6
Transgene: Tg(Thy1-App*R609D*K612E)6Vln  Location: unknown  
Alliance: Tg(Thy1-App*R609D*K612E)6Vln page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-App*R609D*K612E)6Vln expresses 1 gene
 
Mutation detailsMurine APP cDNA modified to have 2 mutations, Arg609 to Asp and Lys612 to Glu, was inserted into the mouse Thy1 gene, replacing a 1.5 kb fragment containing part of the sequence spanning from within exon 2 into exon 4. The thymus-specific elements in intron 3 were deleted in the construct. The construct was microinjected into fertilized 1.5-day-old pre-nuclear embryos from FVB females. RT-PCR verified expression of the transgene in the brain of heterozygotes at ~50% of endogenous App message. Line 6 was established. (J:32213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:32213 Moechars D, et al., Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. EMBO J. 1996 Mar 15;15(6):1265-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory