Tg(Thy1-MAPT)1Vln
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT)1Vln
• Name: transgene insertion 1, Fred Van Leuven
• MGI ID: MGI:3720113
• Synonyms: htau40-1, tau-4R/2N, thy-1.1-tau
• Transgene: Tg(Thy1-MAPT)1Vln Location: unknown
• Alliance: Tg(Thy1-MAPT)1Vln page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT)1Vln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: Human MAPT cDNA encoding the longest tau isoform of 441 amino acids (called tau40) containing four repeats, with 2 N-terminal inserts was inserted into a murine Thy1 expression vector. Founder line 1 was established by breeding with FVB/N females. Expression of human tau (MAPT) protein exclusively in brain and spinal cord was detected by Western blotting. (J:100972)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100972 Spittaels K, et al., Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am J Pathol. 1999 Dec;155(6):2153-65
• All: 7 reference(s)