Imacq^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Imacq^C57BL/6J
• Name: isoflurane minimum alveolar concentration QTL; C57BL/6J
• MGI ID: MGI:3720164
• QTL: Imacq Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased isoflurane minimum alveolar concentration compared to LP/J. (J:123468)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:123468

Linkage analysis was performed on 90 animals from a C57BL/6J x (C57BL/6J x LP/J)F1 backcross to identify QTLs associated with isoflurane minimum alveolar concentration (MAC). A panel of 65 polymorphic markers was used for genome scan. Parental strain LP/J displays higher isoflurane MAC compared to parental strain C57BL/6J. The highest linkage was detected at 15 cM on mouse Chromosome 7 near D7Mi246 (LOD=1.7), corresponding to 30 Mb. C57BL/6J-derived alleles confer increased isoflurane MAC at this locus. SNP analysis of 19 inbred strains confirmed association of isoflurane MAC with the proximal chromosome 7 QTL. This locus is named Imacq (isoflurane minimum alveolar concentration QTL). Previously identified QTL mapping to chromosome 7 include Lorp1 (40 cM) and Etan1 (29 cM).

References

• Original: J:123468 Cascio M, et al., Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration. Anesth Analg. 2007 Aug;105(2):381-5
• All: 1 reference(s)