Del(11Cxcl16-Zmynd15)1Ifc
Targeted Allele Detail

Summary

• Symbol: Del(11Cxcl16-Zmynd15)1Ifc
• Name: deletion, Chr 11, Israel F Charo
• MGI ID: MGI:3720171
• Synonyms: Cxcl16^-, Cxcl16^tm1Ifc, Cxcl16/Zmynd15^tm1Ifc
• Gene: Del(11Cxcl16-Zmynd15)1Ifc Location: unknown Genetic Position: Chr11, Syntenic

Spermatogenic disruption in the testes of Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123851
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(11Cxcl16-Zmynd15)1Ifc involves 2 genes/genome features (Cxcl16, Zmynd15) View all
• Mutation details: A neomycin resistance cassette replaced the entire coding sequence of Cxcl16 and a portion of the overlapping 5'UTR of Zmynd15. Quantitative RT-PCR confirmed the absence of both transcripts. (J:123851)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Cxcl16-Zmynd15)1Ifc Mutation: 0 strains or lines available

References

• Original: J:123851 Aslanian AM, et al., Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation. 2006 Aug 8;114(6):583-90
• All: 2 reference(s)