Nr5a2^tm1Sjns
Targeted Allele Detail

Summary

• Symbol: Nr5a2^tm1Sjns
• Name: nuclear receptor subfamily 5, group A, member 2; targeted mutation 1, Kristina Schoonjans
• MGI ID: MGI:3720193
• Synonyms: Lrh-1^L2
• Gene: Nr5a2 Location: Chr1:136770309-136888186 bp, - strand Genetic Position: Chr1, 59.98 cM, cytoband E4
• Alliance: Nr5a2^tm1Sjns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123697
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 4 and 5. A neo cassette flanked by frt sites was subsequently removed via Flp mediated recombination. (J:123697)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr5a2 Mutation: 96 strains or lines available

References

• Original: J:123697 Coste A, et al., LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13098-103
• All: 23 reference(s)