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Igktm2Ybgn
Targeted Allele Detail
Summary
Symbol: Igktm2Ybgn
Name: immunoglobulin kappa chain complex; targeted mutation 2, Yehudit Bergman
MGI ID: MGI:3720251
Synonyms: D23kappai, D23mCkappa
Gene: Igk  Location: Chr6:67532620-70703738 bp, + strand  Genetic Position: Chr6, 30.89 cM, cytoband F1-pter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123344
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to contain the pre-rearranged D23VkJk5 sequence driven by its endogenous promoter. A loxP site flanked neomycin resistance gene cassette was removed through cre-mediated recombination. (J:123344)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igk Mutation:  26 strains or lines available
References
Original:  J:123344 Fraenkel S, et al., Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol. 2007 Jul;8(7):715-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory