Pdcd1lg2^tm2Shr
Targeted Allele Detail

Summary

• Symbol: Pdcd1lg2^tm2Shr
• Name: programmed cell death 1 ligand 2; targeted mutation 2, Arlene H Sharpe
• MGI ID: MGI:3720327
• Synonyms: PD-L2^-
• Gene: Pdcd1lg2 Location: Chr19:29388319-29448561 bp, + strand Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
• Alliance: Pdcd1lg2^tm2Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123785
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A targeting vector replaced the IgV exon with a hygromycin resistance gene. (J:123785)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdcd1lg2 Mutation: 25 strains or lines available

References

• Original: J:123785 Keir ME, et al., Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med. 2006 Apr 17;203(4):883-95
• All: 7 reference(s)