Il25^tm1Dart
Targeted Allele Detail

Summary

• Symbol: Il25^tm1Dart
• Name: interleukin 25; targeted mutation 1, David Artis
• MGI ID: MGI:3720348
• Synonyms: Il-25^-
• Gene: Il25 Location: Chr14:55170152-55173294 bp, + strand Genetic Position: Chr14, 28.0 cM
• Alliance: Il25^tm1Dart page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123808
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a lacZ and floxed neo cassette. Flp-mediated recombination was used to remove the neo cassette. (J:123808, J:125296)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il25 Mutation: 15 strains or lines available

References

• Original: J:123808 Owyang AM, et al., Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med. 2006 Apr 17;203(4):843-9
• All: 6 reference(s)