Tg(APOE-DGAT2)1Far
Transgene Detail
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Symbol: |
Tg(APOE-DGAT2)1Far |
Name: |
transgene insertion 1, Bob Farese |
MGI ID: |
MGI:3720367 |
Synonyms: |
Liv-DGAT2-high |
Transgene: |
Tg(APOE-DGAT2)1Far Location: unknown
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Alliance: |
Tg(APOE-DGAT2)1Far page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(APOE-DGAT2)1Far expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
DGAT2 (84649) |
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Mutation details: The LivLE6-DGAT2 transgene was designed with promoter and enhancer sequences of the human apolipoprotein E gene placed upstream of a 1.2 kb human acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) cDNA sequence. This transgene was microinjected into C57BL/6NHsd fertilized eggs, and the resulting transgenic offspring were bred to C57BL/6NHsd. Mice from a higher-expressing founder line (referred to as Liv-DGAT2-high) have increased total hepatic DGAT2 mRNA/protein expression relative to the Liv-DGAT2-low line, with no reported overexpression in kidney, brain, or skeletal muscle.
(J:124005)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:124005 Monetti M, et al., Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 2007 Jul;6(1):69-78 |
All: |
1 reference(s) |
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