Il25^tm1Anjm
Targeted Allele Detail

Summary

• Symbol: Il25^tm1Anjm
• Name: interleukin 25; targeted mutation 1, Andrew N J McKenzie
• MGI ID: MGI:3720374
• Synonyms: Il25^-
• Gene: Il25 Location: Chr14:55170152-55173294 bp, + strand Genetic Position: Chr14, 28.0 cM
• Alliance: Il25^tm1Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123748
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a neomycin selection cassette into exon 2 to replace the nucleotides encoding amino acids 22-86. RT-PCR confirmed absence of transcript in mutant mast cells. (J:123748)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il25 Mutation: 16 strains or lines available

References

• Original: J:123748 Fallon PG, et al., Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med. 2006 Apr 17;203(4):1105-16
• All: 19 reference(s)