Esrrb^tm1.2Nat
Targeted Allele Detail

Summary

• Symbol: Esrrb^tm1.2Nat
• Name: estrogen related receptor, beta; targeted mutation 1.2, Jeremy Nathans
• MGI ID: MGI:3720482
• Synonyms: Nr3b2^-
• Gene: Esrrb Location: Chr12:86407891-86568402 bp, + strand Genetic Position: Chr12, 40.49 cM
• Alliance: Esrrb^tm1.2Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124941
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Breeding of Nr3b2^tm1.1Nat mice to Cre-expressing mice results in deletion of the exon containing the initiator methionine codon and encoding the N-terminal 132 amino acids (including part of the DNA-binding domain) in the cre-expressing tissue(s). (J:124941)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esrrb Mutation: 211 strains or lines available

References

• Original: J:124941 Chen J, et al., Estrogen-Related Receptor beta/NR3B2 Controls Epithelial Cell Fate and Endolymph Production by the Stria Vascularis. Dev Cell. 2007 Sep;13(3):325-37
• All: 2 reference(s)