Tg(DMD-APP*)7Neve
Transgene Detail

Summary

• Symbol: Tg(DMD-APP*)7Neve
• Name: transgene insertion 7, Rachel L Neve
• MGI ID: MGI:3720652
• Synonyms: APP-C100, BetaAPP-C104
• Transgene: Tg(DMD-APP*)7Neve Location: unknown
• Alliance: Tg(DMD-APP*)7Neve page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(DMD-APP*)7Neve expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes the C terminal 100 amino acids.

• Mutation details: A fragment consisting composed of the sequence ot the terminal 100 amino acids of the beta-amyloid precursor protein (APP) gene (C104, referred to as C100 in J:100978 which states that the transgene contains the terminal 100 amino acids of APP) was inserted into a plasmid encoding the neural-specific dystrophin (DMD) promoter. The vector also contained the SV40 early splice and polyadenylation sequences. Several founder lines were identified, but line 7 was the most extensively characterized line. RT-PCR of tissues from 6-month old mice revealed predominant expression in the brain (>10-fold higher than in any other tissue where low level-transcription was detected). (J:100978, J:105050)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105050 Kammesheidt A, et al., Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10857-61
• All: 2 reference(s)