Catsper3^tm1Wyan
Targeted Allele Detail

Summary

• Symbol: Catsper3^tm1Wyan
• Name: cation channel, sperm associated 3; targeted mutation 1, Wei Yan
• MGI ID: MGI:3720684
• Synonyms: Catsper3^-
• Gene: Catsper3 Location: Chr13:55932381-55956811 bp, + strand Genetic Position: Chr13, 30.06 cM, cytoband B2
• Alliance: Catsper3^tm1Wyan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124054
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were replaced by a pgk-HPRT cassette in reverse orientation. These exons encode amino acids 152-257, which contain the pore forming region located between the fifth and sixth transmembrane domains of the gene. Northern blot confirmed that the transcript was truncated. (J:124054)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Catsper3 Mutation: 28 strains or lines available

References

• Original: J:124054 Jin J, et al., Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. Biol Reprod. 2007 Jul;77(1):37-44
• All: 1 reference(s)