Bdnf^{tm1(BDNF)Gogo}
Targeted Allele Detail

Summary

• Symbol: Bdnf^{tm1(BDNF)Gogo}
• Name: brain derived neurotrophic factor; targeted mutation 1, Joseph A Gogos
• MGI ID: MGI:3720708
• Synonyms: Bdnf^met
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^{tm1(BDNF)Gogo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124050
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Bdnf^{tm1(BDNF)Gogo} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BDNF (627)

  Bdnf	(MGI:88145)

• Mutation details: A targeting vector was designed to replace the coding sequence with the corresponding 274 bp long human sequence carrying a methionine substitution. The vector contained the self-excising ACN cassette. (J:124050)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:124050 Cao L, et al., Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo. Curr Biol. 2007 Jun 5;17(11):911-21
• All: 2 reference(s)